To avoid danger zone, aircraft diverted to airports in locations including Istanbul, Baku and Cyprus.
Iranians are attempting to understand what to do following airstrikes on residential areas across Tehran.
Turkey's stock exchange leads global losses, even exceeding those seen in Tehran and Tel Aviv. Ankara, meanwhile, keeps nervous eye on oil price.
Iranian President strikes out at Israel for airstrikes against Iran on June 13.
US President Donald Trump posted on Truth Social that he gave Iran "chance after chance to make a deal" but they "just couldn't get it done," warning of escalating military action if Tehran refuses negotiations.
Israel has launched a second wave of airstrikes targeting Iranian cities, with reports confirming explosions in Shiraz and Tabriz on June 13 targeting military installations.
Mohammad Bagher Ghalibaf, Speaker of Iran's Parliament, has vowed revenge against Israel following strikes on Iranian nuclear and military facilities
Commercial aircraft evacuated from airspace above Israel, Iran, Iraq and Jordan on June 13 after Israeli forces launched attacks targeting Iranian facilities.
The drone attacks came in response to what Defence Minister Israel Katz confirmed was a "pre-emptive strike" conducted by Israeli forces against Iranian targets.
Israel launched an extensive aerial attack on Iran in the early hours of June 13, striking multiple locations across Tehran and other key cities, in what it described as a pre-emptive operation against military and nuclear infrastructure.
Residents across Tehran reported hearing powerful explosions late on June 12, with loud blasts felt from Chitgar and Mehrabad in the west to Shahid Mahalati residential comples in the northeast.
Iran has announced plans to significantly increase its enriched uranium production and establish a third, highly secure enrichment facility
Oman has confirmed it will host the sixth round of indirect negotiations between Iran and the United States on June 15, following the departure of US personnel from the region.
Israel is on the brink of attacking Iran, with action expected within days.
Iran's Foreign Minister Abbas Araghchi said on June 11 that an agreement that can ensure the continued peaceful nature of Iran's nuclear programme is within reach and could be achieved rapidly.
Israeli police have arrested a 13-year-old Tel Aviv boy suspected of carrying out missions for Iran.
Iran and Venezuela will finalise their long-awaited free trade agreement, with the text and annexes set for ministerial signing by June 12, the head of Iran's Trade Promotion Organisation said.
Iran has escalated its rhetoric against Israel and certain European nations, claiming that recently obtained "strategic intelligence documents" demonstrate active Israeli participation in shaping the views of parties negotiating with Iran.
Iran has declared what it claims to be one of the largest intelligence operations in history against Israel.
Iran's foreign minister has warned of a strong reaction to European accusations of nuclear non-compliance in a worsening situation between the sides.