Iran launched missiles at Israel on June 7 in the first direct Iranian strike since a fragile ceasefire took effect in early April, in response to Israeli air raids on Hezbollah targets in Beirut's southern suburbs, state media reported.

The escalation threatens the Pakistan-mediated talks aimed at ending the war that began in February, with US President Donald Trump saying he would urge Israel against retaliation to preserve the prospect of a deal after a day of discussions between Pakistani and Iranian officials.

Israel struck the Beirut suburb of Dahiyeh after Hezbollah fired missiles into northern Israel, and the Iranian barrage followed, drawing competing claims over interception and damage.

The Revolutionary Guard said the launches used long-range solid-fuel missiles and described the operation as a warning, threatening wider strikes on US and Israeli targets in the region if attacks continued. It added that the strike was using a new upgraded missile with messages scribbled on it in a show of continuing defiance by Tehran. 

It said it had targeted the Ramat David air base in northern Israel as the origin of the assault on Beirut's suburbs.

Iran's armed forces emergency command chief, Major General Ali Abdollahi, said Israel must halt its attacks on southern Lebanon, warning that any expansion or retaliation against Iran would be met with crushing blows.

The Israel Defense Forces said its air defences were deployed nationwide and that all missiles launched from Iran had been intercepted. IDF spokesperson Brigadier General Effie Defrin said the Iranian regime had made a grave error and that the military was preparing plans for a continued response.

Israel's emergency service reported no casualties from the strikes, though a 79-year-old woman was moderately hurt on her way to a shelter in the north. Schools were cancelled nationwide and public shelters opened in Haifa.

Trump told Channel 12 he would call Israeli Prime Minister Benjamin Netanyahu to urge restraint, saying the missile fire had hit no one and that a final agreement with Iran was close.

"I'm going to call Bibi now and tell him not to respond," Trump said.

Iranian Foreign Minister Abbas Araghchi held calls with his Turkish, French, Qatari and British counterparts and Pakistani mediators.